Spoiler:
- Fry's true destiny. I think that the Brainspawn were only part of it.. inevitably he'll end up saving the universe (again), somehow.

- "The Other".. I know that this is Leela, but what does this mean?

- The whole "Fry / Leela" relationship. The new series is supposed to be two years in the future since "The Devil's Hands are Idle Playthings".. and I know that many shippers really want them to be together, but I am sure they are going to be sorely disappointed when the first DVD comes out. I think they are going to be a bit closer than they were in the TV series, but still not in any relationship. My guess is that they will finally get together near the end of the last DVD and get married, because that way the producers can give the fans what they want and not risk ruining the rest of the series (since there would be no more).

- I've read this article from this site: http://www.aintitcool.com/display.cgi?id=24076

I have no idea whether to believe any of it or not, since a lot of false and misleading stuff has spread over the years. But there's a few things I'd like to go over.. like first of all, Seymour. Leave the poor dog rest in peace.. but I have this feeling that there's going to be yet another tearjerking moment with him, but Fry will see it this time (as if one wasn't enough).

This line tells me a lot (if any of that article is even true): By episode's end, the world of Futurama is left more or less unchanged..

To me, this means that nothing that anyone is expecting / predicting is going to happen (on the first DVD, at least). But that doesn't matter very much since there will still be three more to go. The first DVD will be more like a reintroduction to everyone, what's been happening to them in the past two years, etc..

If you haven't guessed by now, then yes.. I am a Fry / Leela shipper. Just not very rabid, I think..

Spoiler:
I was expecting Peter to lose control and use Sylar's telekinesis to slice Isaac's head open and kill him (since in the future Hiro went to, he was dead in that way and there was a gun on the floor next to him similar to the one he had), but no.. Simone just happens to pop out of nowhere and get shot.

Spoiler:
1. Fry or Leela dying.

2. Fry and Leela remaining friends and marrying other people (think of The Wonder Years. The fact that Kevin didn't end up with Winnie after all of that sucked big time).

3. Fry waking up (on December 31, 1999) to find out it was all a dream.. and then either freezes himself or ends up frozen again in the same way, starting the whole series over.

4. After the last scene, the screen zooming out showing somebody looking into a What-If Machine (like Nibbler, showing what would happen if he pushed Fry in to be frozen in 1999.. ie. the whole series. He'd then say to himself that Fry is the "Mighty One" and leave to Earth, starting the whole chain from the beginning).

Actually, I kind of like that last one.